For those of you new to this conversation high levels of a protein called Osteopontin have been implicated as the cause of Scoliosis. Interestingly enough Osteopontin has been associated with numerous cancers and other potentially fatal inflammatory diseases.
This morning I read that Osteopontin has been connected to contact allergies.
Osteopontin Contributes to Allergic Contact Dermatitis
Bonus Links
Genetically removing the osteopontin protein prevents lung diseases
Osteopontin linked to autoimmune disease relapses
High plasma osteopontin levels in patients with inflammatory bowel disease.
This morning I read that Osteopontin has been connected to contact allergies.
Osteopontin Contributes to Allergic Contact Dermatitis
They found that both skin cells and immune cells secreted OPN in allergic contact dermatitis lesions. OPN was strongly induced in antigen-specific immune cells in a murine model of chronic contact hypersensitivity, and OPN-deficient mice had a less severe chronic contact hypersensitivity response. As anti-OPN antibody treatment partially suppressed the symptoms of chronic contact hypersensitivity, OPN may serve as a new therapeutic target for allergic contact dermatitis.
Genetically removing the osteopontin protein prevents lung diseases
Osteopontin linked to autoimmune disease relapses
High plasma osteopontin levels in patients with inflammatory bowel disease.
Comment