Apparently no. From Jack Cheng's "top theories" paper...
Elsewhere, it has been stated that the putatively autosomal dominant form and the mutifactorial form are not distinguishable in many/most(?) regards. I suspect that is why he suggests even what looks like straight autosomal dominant inheritance is probably multifactorial genetic inheritance. This would explain why the cases are not distinguishable according to some.
And last...
When you add the Scoliscore work which shows a genetic control on progression (or at least an ability to predict when a curve will not progress to >40*), then both incidence and progression appear to be under genetic control.
A clear mode of inheritance of AIS has not been confirmed and reports on autosomal dominant,7 dominant major gene di-allele model,8 X-linked,9,10 or multifactorial inheritance pattern 11,12 have all been reported.
Even in the familial AIS cases, it is likely that multifactorial inheritance is implicated. Another aspect of the genetic study of AIS as a complex trait disease is finding the difference between familial AIS and sporadic ones. In a recent report,27 it was observed that the first-degree familial AIS girls had more severe curve and longer arm span than sporadic ones. Further subgrouping of AIS subjects for genetic analysis would be an important approach.
And last...
Multiple reports are available to support the role of inheritance in the development of AIS.
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