Originally posted by Pooka1
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Advanced Maternal Age Associated with AIS?
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Originally posted by Ballet Mom View PostYes, those scientists are pretty unreliable, especially here in the US where we get to throw out the politically unfavorable studies.
Apparently we should probably stop funding scientists because nothing they do is valid.
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Originally posted by Ballet Mom View Post
Familial scoliosis means that there are other cases of scoliosis in the family tree. Adolescent Idiopathic Scoliosis means they don't know what causes it.
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Originally posted by Pooka1 View PostYou are assuming "positive family history" = "familial" in the technical sense that researchers use the term. I don't think that is the case. All AIS seems to be considered "familial" per at least some references.
This seems to be a similar problem with "environmental" and "multifactorial."
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Originally posted by Pooka1 View PostThey may think the studies are valid but most published studies are false FULL STOP.
Apparently we should probably stop funding scientists because nothing they do is valid.
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Originally posted by Ballet Mom View PostHow do you come up with that?
This seems to be a similar problem with "environmental" and "multifactorial."
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Originally posted by Pooka1 View PostYou posted this...
I think this might be the explanation for that
http://books.google.com/books?id=Ivw...page&q&f=false
It says that there is a family history in about 1/3 of the cases. I don't think that means the other cases with no close relative are not familial but I'm not sure. That wouldn't make sense given that AIS is hereditary.
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Originally posted by Ballet Mom View PostSo apparently the neurosurgeons and orthopedic surgeons of Australia, Britain, Sweden and the United States aren't capable of deciding whether studies are valid, but you are. Interesting.
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Originally posted by Pooka1 View PostThe first reference doesn't seem to disagree with all AIS being familial.
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You posted this...
Adolescent idiopathic scoliosis (IS) is the most common spine deformity arising during childhood, but the etiology of IS remains unknown. A large proportion (75%) of structural scoliosis is clinically classified as idiopathic [1]. Idiopathic scoliosis often appears in several members of the same family, this strongly suggesting a genetic transmission. Clinical studies indicate that approximately 1:4 of the total scoliosis cases and 1:3 of idiopathic scoliosis cases are familial [2].
http://books.google.com/books?id=Ivw...page&q&f=false
It says that there is a family history in about 1/3 of the cases. I don't think that means the other cases with no close relative are not familial but I'm not sure. That wouldn't make sense given that AIS is hereditary.
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i never said that...
now i remember why i don't respond to your posts...
most educated and intelligent people are capable of deciding for themselves whether or not a study is valid..
i don't worship any researcher or scientist...or their opinions...
just because a study was conducted doesn't make it valid...
there are many flawed studies being pointed to as proving something...
and many unimpressive studies...
and even more studies with small numbers of participants that try to generalize to larger populations...
but people can believe whatever they wish...
"wish" being the key word there
jess
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The first reference doesn't seem to disagree with all AIS being familial.
I can't find the Weinstein reference in the second one to see what exactly they are talking about but I think the term "familial" may be used differently by different researchers. Some say all AIS is familial so I guess we have to look at the evidence for that being or not not being the case. I can say nobody else appears to reference that Weinstein paper except the paper you cite. I wonder if it is a mistake.
ETA: I found another paper that references Weintstein
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Originally posted by Pooka1 View Post
"I read that familial cases are 25% of the AIS cases, so they are actually a subset of the larger scoliosis population. "
http://hmg.oxfordjournals.org/conten...mg.ddq571.full
Genetic contributions to AIS have been described for decades (10). About one quarter of AIS patients report a positive family history of disease, and twin studies have consistently supported shared genetic factors in disease (reviewed in 4,5).
Or here:
Adolescent idiopathic scoliosis (IS) is the most common spine deformity arising during childhood, but the etiology of IS remains unknown. A large proportion (75%) of structural scoliosis is clinically classified as idiopathic [1]. Idiopathic scoliosis often appears in several members of the same family, this strongly suggesting a genetic transmission. Clinical studies indicate that approximately 1:4 of the total scoliosis cases and 1:3 of idiopathic scoliosis cases are familial [2].
http://www.scoliosisjournal.com/content/1/1/21
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Originally posted by jrnyc View Postonly if studies are valid are they worthy of attention...
all kinds of studies have been done with faulty methods, or other factors that make
them invalid
studies with small numbers of participants do not mean much to me...regardless of whether i "like" what the studies claim to prove or not...
jess
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Originally posted by Ballet Mom View PostThe "guilt trip" due to maternal age seems to be a repeating theme on this thread. I don't understand why it would make anyone feel guilty....what could they have done differently?
And if there are a bunch of studies that all show roughly the same thing, it wouldn't be up to people to just discard them because they don't like what they say.
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