I could also be convinced that the familial type of scoliosis is different from the multifactorial AIS, although probably similar. It just seems to me that their inheritance is much different that what we have experienced in our genetic tree. It seems like most of the juvenile cases of scoliosis come from familial-type scoliosis families. That may be incorrect, but it sure seems to be the case on this forum.
Juvenile cases are much more intent on climbing to surgical range no matter the treatment. Are the non-juvenile familial cases also harder to treat? Familial cases are what has been used to create the Scoliscore...should it really only be used on familial cases? It may not be predicting anything on the multifactorial cases of scoliosis.
I read that familial cases are 25% of the AIS cases, so they are actually a subset of the larger scoliosis population. And I suppose people might have been classified in that 25% such as my family even though they only have a distant family relationship.
Perhaps the familial cases are simply unlucky in having some gene like the double-jointedness gene present on both sides of the family tree and therefore get a much greater genetic influence than those that only have in on one side of the family tree. This doesn't mean that those with greater joint hyper-extension would get larger cases of scoliosis because there are girls with truly huge hyper-extension in their knees which have less scoliosis in ballet then my daughter. Maybe it just affects the progression for some reason.
In any case, I really think they need to determine who has the true familial type of scoliosis and consider them as possibly distinct from the probably more environmentally influenced cases, when considering genetic research and testing.
Juvenile cases are much more intent on climbing to surgical range no matter the treatment. Are the non-juvenile familial cases also harder to treat? Familial cases are what has been used to create the Scoliscore...should it really only be used on familial cases? It may not be predicting anything on the multifactorial cases of scoliosis.
I read that familial cases are 25% of the AIS cases, so they are actually a subset of the larger scoliosis population. And I suppose people might have been classified in that 25% such as my family even though they only have a distant family relationship.
Perhaps the familial cases are simply unlucky in having some gene like the double-jointedness gene present on both sides of the family tree and therefore get a much greater genetic influence than those that only have in on one side of the family tree. This doesn't mean that those with greater joint hyper-extension would get larger cases of scoliosis because there are girls with truly huge hyper-extension in their knees which have less scoliosis in ballet then my daughter. Maybe it just affects the progression for some reason.
In any case, I really think they need to determine who has the true familial type of scoliosis and consider them as possibly distinct from the probably more environmentally influenced cases, when considering genetic research and testing.
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