Principles in bone Psysiology
Dingo -
Attached is a paper I found that may help explain some of Frost's work (which appears to have been continued throughout the last few years). I'll be away from forum for a few days but thought you would want this.
ABSTRACT
The view that nonmechanical agents dominate control of osteoblasts and osteoclasts and thus postnatal changes in bone strength and mass (agent-effector cells-disease) is obsolete. Nonmechanical agents include hormones, calcium, vitamin D, cytokines, gender, genetics, etc. This paradigm overlooks all tissue level features, biomechanics and relationships found after 1960. This more recent information led to the Utah paradigm of skeletal physiology, proposed by Harold Frost in 1995. The Utah paradigm's view is that mechanical factors dominate control of the biologic mechanisms that control changes in postnatal bone and mass. Nonmechanical agents could help or hinder the influence of the mechanical factors but could not replace them. The simplified scheme is as follows:
Who is Harold M Frost: http://en.wikipedia.org/wiki/Harold_Frost
One of the most often cited investigators in skeletal research according to Science Citation Index
Originally posted by Dingo
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Attached is a paper I found that may help explain some of Frost's work (which appears to have been continued throughout the last few years). I'll be away from forum for a few days but thought you would want this.
ABSTRACT
The view that nonmechanical agents dominate control of osteoblasts and osteoclasts and thus postnatal changes in bone strength and mass (agent-effector cells-disease) is obsolete. Nonmechanical agents include hormones, calcium, vitamin D, cytokines, gender, genetics, etc. This paradigm overlooks all tissue level features, biomechanics and relationships found after 1960. This more recent information led to the Utah paradigm of skeletal physiology, proposed by Harold Frost in 1995. The Utah paradigm's view is that mechanical factors dominate control of the biologic mechanisms that control changes in postnatal bone and mass. Nonmechanical agents could help or hinder the influence of the mechanical factors but could not replace them. The simplified scheme is as follows:
Who is Harold M Frost: http://en.wikipedia.org/wiki/Harold_Frost
One of the most often cited investigators in skeletal research according to Science Citation Index
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