Another thought - if the course of JIS is as serious as stated (90% progressing) then a study which simply accepted every JIS patient and showed no progression among any of them would be promising. Not definitive by any means, but certainly promising.
But, not among AIS patients, given the large percentage that don't progress. Among them, there would either have to be a reduction (almost an impossible request) or a really good controlled study.
This, the other side of the coin, is the reason why I don't understand how people can reject alternative treatments because they haven't shown a clear result. A clear result is extremely hard to show, since the most likely result of a good intervention is simply that a curve does not progress, and one can always say that maybe it wouldn't have progressed anyway. Even a controlled studied is so likely to mix in patients with different kinds of etiologies, curves, ages, etc.
But, not among AIS patients, given the large percentage that don't progress. Among them, there would either have to be a reduction (almost an impossible request) or a really good controlled study.
This, the other side of the coin, is the reason why I don't understand how people can reject alternative treatments because they haven't shown a clear result. A clear result is extremely hard to show, since the most likely result of a good intervention is simply that a curve does not progress, and one can always say that maybe it wouldn't have progressed anyway. Even a controlled studied is so likely to mix in patients with different kinds of etiologies, curves, ages, etc.
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