"In 2006 a group of Stanford researchers attempted to tease apart this question. The scientists measured pain thresholds in patients with back pain before and after four months of oral morphine. The researchers found that the patients had become significantly more sensitive to pain by the study's end."
https://www.npr.org/sections/health-...ake-pain-worse
https://www.npr.org/sections/health-...ake-pain-worse
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