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    Mar 2009

    Neuroinflammatory signals drive Scoliosis in Zebrafish model

    Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis.

    December 12, 2018

    The etiopathogenesis of idiopathic scoliosis (IS), a highly prevalent spinal deformity that occurs in the absence of obvious congenital or physiological abnormalities, is poorly understood. Although recent zebrafish genetic studies have linked cilia motility and cerebrospinal fluid (CSF) flow defects with scoliosis progression, underlying mechanisms were not identified. Here, we use next-generation sequencing and conditional genetic methodologies to define the spatial and biological origins of spinal curve formation in ptk7 mutant zebrafish, a faithful IS model. We demonstrate that focal activation of proinflammatory signals within the spinal cord is associated with, and sufficient for, induction of spinal curvatures. Furthermore, administration of acetylsalicylic acid (aspirin) or N-acetylcysteine (NAC) to juvenile ptk7 mutants significantly reduces the incidence and/or severity of scoliosis phenotypes. Together, our results implicate neuroinflammation, downstream of CSF defects, in spinal curve formation and provide intriguing evidence that simple immunomodulating therapies might prove effective in managing idiopathic-like spinal deformities.

    As is so often the case among common diseases inflammation may be the root cause of scoliosis. That appears to be the case in the Zebrafish model that researchers use to study IS.

    Long story short: Eat your vegetables and don't eat processed food garbage. Hopefully ever. Modern, sugary food is highly inflammatory. Google for confirmation on diet and inflammation.
    Last edited by Dingo; 12-15-2018 at 10:04 AM.

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