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Thread: Why we need the final Cobbs in BrAIST

  1. #1
    Join Date
    Jan 2008
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    NC
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    Why we need the final Cobbs in BrAIST

    2016 SRS meeting

    http://srs.gmetonline.com/ViewPresen...onpackageid=12

    1. post brace progression rate higher than natural history

    2. Curve magnitude at completion ALONE is predictive of post-brace surgical progression. (This is what the BrAIST authors need to address in their results. Because they didn't publish the post-bracing curve magnitudes, and because curves up to 49* with up to 25% growth remaining were bracing "successes", it is IMPOSSIBLE to use their results to determine how much bracing avoids surgery.)

    3. >80% of patients who completed bracing at > or = 45* reached post-brace surgical progression.

    4. no patient who completed bracing with < 40* failed.

    5. no patient with brace initiation at Risser II had post-brace surgical progression.
    Last edited by Pooka1; 02-26-2017 at 12:43 AM.
    Sharon, mother of identical twin girls with scoliosis

    No island of sanity.

    Question: What do you call alternative medicine that works?
    Answer: Medicine


    "We are all African."

  2. #2
    Join Date
    May 2021
    Posts
    6

    Distaste for BrAIST

    So true, a lot of material info was missing from the report. Not to mention stopping the study early distorts the results. Ended up being a small number of people in the not very randomized trial.

  3. #3
    Join Date
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    NC
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    The main problem continues to be that researchers have to measure something objective (like whether a Cobb is >49* with less than 25% growth remaining) versus what patients and parents really need to know (will bracing avoid surgery for life?).

    There is a reason the final Cobb angles were not published for the BrAIST study. It is because their conclusions would have to change in terms of some of these bracing "successes" would be seen as OBVIOUS failures in terms of needing surgery.
    Sharon, mother of identical twin girls with scoliosis

    No island of sanity.

    Question: What do you call alternative medicine that works?
    Answer: Medicine


    "We are all African."

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