Originally posted by Pooka1
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Lonstein JE, Bjorklund S, Wanninger MH, et al. Voluntary school screening
for scoliosis in Minnesota. J Bone Joint Surg Am 1982;64:481–8.
Originally posted by Pooka1
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Scoliosis in twins. A meta-analysis of the literature and report of six cases. - this study has 37 MZ and 31 DZ cases. What part of your argument am I missing here?
Originally posted by Pooka1
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Originally posted by Pooka1
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But the oversampling of more severe curves is definitely the case. From that thread:
I'm stating that they ARE more severe. The meta-analysis you posted confirms that. So the patients being counted in these studies, not only have scoliosis, but are being treated for it. Only 4 pairs of the monozygotic twins both had curves <20° (none of the dizygotic). The remainder had at least one, and most were both, curves >25°. So this is a decidedly biased group toward more severe curves. So the concordance rate being higher for more severe curves makes sense to me in light of the scoliscore data.
It's true, what you're saying, that less severe curves might have a protective genetic link as well. Nobody knows for sure. But it doesn't take away from my point that, for many curves that are in need of clinical follow-up have a measurable genetic link. Thus, MZ twins needing clinical follow-up would have higher concordance since their scoliscore would be the same.
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