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New review paper on AIS etiology

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  • New review paper on AIS etiology

    https://www.asianspinejournal.org/up...-2018-0096.pdf

    Abstract
    Adolescent idiopathic scoliosis (AIS) is the peripubertal development of spinal curvature of a minimum of 10. AIS is thought to be
    attributable to genetic factors, nutrition, early exposure to toxins, and hormonal dysregulation. Recent literature suggests these factors may compound to determine both disease onset and severity. Currently, treatment is limited to observation, bracing, and surgical
    intervention. Intervention is presently determined by severity and risk of curve progression. As they emerge, new therapies may target
    specific etiologies of AIS.

    Introduction
    Adolescent idiopathic scoliosis (AIS) is the most common
    type of scoliosis affecting 2%4% of adolescents, mainly
    involving children between 10 and 18 years of age [1]. AIS
    has both congenital and developmental components, with
    the former being studied from the perspective of genetic
    variation. Using comparative genetic methodologies, such
    as genome-wide association studies (GWAS), several
    genomic linkages have been shown to be associated with
    this spine pathology. Thus, it can be determined that AIS
    is polygenic or a quantitative trait locus, which can vary
    due to several different genetic loci. The etiology is not
    limited to genetic predispositions but has been studied in
    association with physiological, anatomical, and hormonal
    disruptions. The literature has been reviewed to provide a
    holistic understanding of AIS etiology.
    Sharon, mother of identical twin girls with scoliosis

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