August 2009: Comparison of the Melatonin and Calmodulin in Paravertebral Muscle and Platelets of Patients With or Without Adolescent Idiopathic Scoliosis
Another study found an asymmetry in children with Scoliosis. This time the asymmetry occured in a protein called Calmodulin found in muscle cells. It should be noted that Calmodulin is significantly impacted by exercise.
You might be asking yourself if this Calmodulin asymmetry in the paraspinal muscles is a cause or consequence of Scoliosis. It's possible that we already have an answer. Two recent studies found that Tamoxifen, a Calmodulin antagonist puts Scoliosis in reverse.
March 2009: The Effect of Calmodulin Antagonists on Experimental Scoliosis: A Pinealectomized Chicken Model
April 2009: The effect of calmodulin antagonists on scoliosis: bipedal C57BL/6 mice model.
Conclusion. AIS group had an asymmetric distribution of calmodulin in paraspinal muscle, higher at the convex side and lower at the concave. Neither platelet melatonin nor platelet calmodulin was found to be representative of the muscle protein values.
You might be asking yourself if this Calmodulin asymmetry in the paraspinal muscles is a cause or consequence of Scoliosis. It's possible that we already have an answer. Two recent studies found that Tamoxifen, a Calmodulin antagonist puts Scoliosis in reverse.
March 2009: The Effect of Calmodulin Antagonists on Experimental Scoliosis: A Pinealectomized Chicken Model
Conclusion. The incidence and magnitude of scoliosis in pinealectomized chicken may be decreased by the administration of TMX, presumably because of this drugs' calmodulin antagonism. Further studies on higher animals and dosage and timing are required.
This study has demonstrated that TMX is effective in changing the natural history of scoliotic deformities in C57BL6 mice model favorably.
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