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Thread: Predicting Brace-Resistant Adolescent Idiopathic Scoliosis

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  1. #5
    Join Date
    Mar 2009
    Location
    Arizona
    Posts
    949

    Blood test / bracing

    The Braist study as well as the genetic test are probably obsolete at this point. It reminds me of the old show biz saying, "here today, gone later today."

    A curve cannot progress without OPN and a simple blood test will tell someone if a brace is doing it's job. If OPN goes down the brace is working, if OPN doesn't go down the brace is a waste of time.

    METHOD OF DETERMINING RISK OF SCOLIOSIS

    [0014] In accordance with another aspect of the present invention, there is provided a method for assessing the efficacy of a brace on a subject having a scoliosis comprising measuring osteopontin (OPN) expression in a sample from the subject prior to and at least once after bracing the subject, wherein an increase in the OPN expression after as compared to prior to bracing the subject is indicative that the brace is ineffective.

    [0015] In a specific embodiment, the determining the OPN expression after the bracing is performed at least one month after the bracing. In another specific embodiment, the determining the OPN expression after bracing the subject is performed at least 2 months after the bracing. In another specific embodiment, the determining the OPN expression after bracing the subject is performed at least three months after the bracing. In another specific embodiment, the determining the OPN expression after bracing the subject is performed at least six months after the bracing.

    [00165] A distribution of AIS patients across the predefined cut-off zones was also performed prior to being treated with bracing and after bracing. Eight patients were tested a certain number of months after bracing, namely for each of patients #1 to 8: 7, 7, 8, 22, 22, 22 and 26 months after bracing, respectively. Figure 16 shows that prior to being treated with bracing (Panel A), 63% of these patients were in the red and yellow zones. A significant shift towards the green zone (<700ng/mL) was observed, which is consistent with the trend observed in surgically treated patients, as presented in Figures 13 -15.
    Last edited by Dingo; 10-01-2009 at 06:04 PM.

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