increased melatonin, increases osteopontin, and suppresses cAMP.
EEEEeeeee... that makes things a bit more complicated. Melatonin suppresses cAMP which in theory should be a good thing. Once again page 5 on this chart shows that children with Scoliosis don't inhibit cAMP properly in response to Melatonin.

I can't get to the study you listed. Does the study suggest that these hormones merely trigger and work together or are they suggesting that something like a Melatonin supplement would cause Osteopontin to shoot up?

For example I can take all the Vitamin B I want and anything over a normal level gets flushed. But if I ate iron supplements like candy my skin would turn orange.