MultiVu Video Feed: Medical Breakthrough at Texas Scottish Rite Hospital for Children Yields First Clue to Understanding Most Common Spinal Deformity in Children



NEW YORK, April 26 /PRNewswire/ -- Researchers have identified the
first gene associated with idiopathic scoliosis (I.S.), a common condition
affecting tens of thousands of adolescents in the U.S. each year. Teens
with scoliosis often have to wear uncomfortable and embarrassing braces or
even undergo major surgery. This genetic discovery lays the groundwork for
future research that will better treat and prevent this condition. With no
known cause or cure, idiopathic scoliosis poses a significant health burden
to the pediatric population. The condition affects approximately two to
three percent of school age children in the U.S. and costs an estimated
several billion dollars in surgical treatment each year.
This discovery is a result of a 10-year study conducted at the Sarah M.
and Charles E. Seay/Martha and Pat Beard Center for Excellence in Spine
Research at Texas Scottish Rite Hospital for Children, led by Carol Wise,
Ph.D. With the goal of identifying genes causing idiopathic scoliosis, the
research team conducted genome-wide scans of 53 large families, totaling
130 individuals with a confirmed I.S. diagnosis, and compared those results
to an independent set of I.S. patients and their families. As a result, the
team identified the first gene associated with I.S., allowing the medical
community to begin to form hypotheses for what causes the condition and
examine ways to prevent I.S.
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NEWS: Researchers Discover First Gene Associated with Idiopathic Scoliosis

FORMAT: Soundbites and B-roll.
SOUNDBITES: Carol Wise, Ph.D, Director of Molecular Genetics at Texas
Scottish Rite Hospital for Children -- lead project researcher
B-ROLL INCLUDES: ***Lab work: working with a database of samples,
handling/testing samples ***Hospital: kids/patients***doctors in group
discussions***Xrays***logo/hospital sign
VIDEO PROVIDED BY: Texas Scottish Rite Hospital for Children