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Thread: FINALLY - Danish Twin study FORMALLY blown out of the water!

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    FINALLY - Danish Twin study FORMALLY blown out of the water!

    OMG. It's a penetrating glimpse into the obvious but it needed to be formally done.

    Please recall what I have said one million times about lay self-reports... garbage in - garbage out. GIGO. Nobody needs to be clairvoyant to see this coming.

    I don't expect to ever see another reference to this study in relation to downplaying the effects of genetics on scoliosis.

    Emphasis added to add emphasis LOL

    Concordance Rates of Adolescent Idiopathic Scoliosis in a Danish Twin Population.
    Simony, Ane; Carreon, Leah Y.; Hjmark, Karen; More
    Spine., Post Author Corrections: May 9, 2016
    Purchase Access Published Ahead-of-Print

    Study Design. Clinical, radiological and genetic determination of zygosity of twin pairs from the Danish Twin Registry who self-reported having Adolescent Idiopathic Scoliosis (AIS).

    Objective. To establish concordance rates of AIS.

    Summary of Background Data. The aetiology of and the true mode of inheritance of AIS remains unclear. Studies on concordance in twin pairs provide a basis for analysing the influence of genetic versus environmental factors. In 2007, using self-report of AIS from the Danish Twin Registry, concordance rates of 0.13 in monozygotic twins and 0.00 in dizygotic twins were reported.

    Methods. All 46,418 twins registered in the Danish Twin Registry born from 1931 to 1982 were sent a survey, which included questions about scoliosis. The survey was returned by 34,944 individuals (75.3%) representing 23,204 pairs. From this study, 548 individuals representing 274 complete twin pairs where at least one twin self-reported having scoliosis were invited to a clinical and radiological examination. Zygosity was established by genetic testing.

    Results. 182 individuals (33.2%) of the original cohort agreed to participate, 128 of whom had scoliosis by self-report. There were 91 twin pairs, where one or both twins had reported scoliosis and 36 individuals whose twin did not want to participate. Only 35 (27%) of the 128 participants with self-reported scoliosis had a clinically and radiologically confirmed curve. Calculating concordance in twins with Cobb angles greater than 10 degrees, we found that the pairwise concordance rate was 0.4 (0.10-0.70) for monozygotic and 0.05 (-0.05 -0.15) for dizygotic twins, p = 0.05, probandwise concordance was 0.45 (0.16-0.74) for monozygotic and 0.1 (-0.03-0.23) for dizygotic pairs.

    Conclusion. Concordance rates in a Danish twin population using genetic testing for zygosity are higher than previously reported using self-report. Although not statistically significant the differences in monozygotic and dizygotic pairs indicate genetic factors may be of importance for scoliosis.

    Level of Evidence: 3
    Last edited by Pooka1; 06-18-2016 at 12:47 PM.
    Sharon, mother of identical twin girls with scoliosis

    No island of sanity.

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