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Thread: More evidence that Early Onset and AIS are very different conditions

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    Join Date
    Jan 2008

    More evidence that Early Onset and AIS are very different conditions

    The curves in each group are statistically different in certain regards.

    Clinically Significant Differences Exist Between Curves in Operative Idiopathic Early-Onset Scoliosis and Adolescent Idiopathic Scoliosis

    McElroy, Mark J.; Sponseller, Paul D.; Fuhrhop, Sara K.; Russell, Colin J.; Newton, Peter O.; Marks, Michelle C.; Sanders, James O.; Yazici, Muharrem; Pawelek, Jeff B.; Akbarnia, Behrooz A.; the Harms Study Group, and the Growing Spine Study Group

    Spine. 38(16):1368-1374, July 15, 2013.


    Study Design. Retrospective analysis.

    Objective. To determine if statistically significant differences exist between operative idiopathic early-onset scoliosis (IEOS) and adolescent idiopathic scoliosis (AIS) in primary curve characteristics, stable vertebra, kyphosis, or lumbar deformity and, if so, to identify the clinical significance of these differences.

    Summary of Background Data. To our knowledge, no study has statistically compared radiographical measures of operative IEOS and AIS.

    Methods. We identified operative patients (60, IEOS; 1537, AIS) in 2 multicenter databases and measured preoperative radiographical parameters of interest. The measurements were compared using the Student t test and other appropriate statistical methods (significance, P= 0.05).

    Results. The IEOS and AIS groups were significantly different in primary curve magnitude (70°± 20°vs. 54°± 13°, respectively; P< 0.001), stable vertebra location (L3.0 ± 1.4 vs. L2.1 ± 2.2, respectively; P= 0.001), and T2 to T12 kyphosis (40°± 15°vs. 31°± 13°, respectively; P< 0.001). Distribution of major curve apex was unimodal centered close to the thoracolumbar junction in IEOS versus bimodal in AIS. Primary curve type was thoracic in 83% and 79% and thoracolumbar/lumbar in 17% and 21% of patients with IEOS and AIS, respectively. When the overall cohorts were separated into curve types and these subsets were compared, statistically significant differences were found between IEOS and AIS in thoracic primary curves (apex, magnitude, direction, proximal and distal Cobb vertebrae, and lumbar deformity) and thoracolumbar/lumbar primary curves (magnitude).

    Conclusion. Significant radiographical differences exist between operative IEOS and AIS curves. IEOS curves are greater in magnitude, more kyphotic, less well compensated, and have a more caudal apex and stable vertebra. These findings suggest that younger patients may require more distal instrumentation and that proximal fixation techniques should consider the additional pullout forces created by the greater kyphosis.

    Level of Evidence: 3
    Last edited by Pooka1; 07-27-2013 at 05:08 PM.
    Sharon, mother of identical twin girls with scoliosis

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