Yes and that would NOT involve the nervous system, yes? It involves function of a gland that changes its programmed secretions, no? So like perhaps environmental estrogen mimic molecules, that is another example of something that is NOT controlled by the nervous system in any way.
Originally Posted by Kevin_Mc
Yes but my point was that the two etiologies being discussed in this thread are mutually exclusive. They can't both be right if they are both claimed to be primary.
Also, while everything requires a genetic component to be translated, a perfectly translated protein can still not function properly because of other, non-genetic influences.
Actually, I read the press release from Wise and she is quite measured about whether those two genes which map to the nervous system are primary. In fact she doesn't claim that as far as I know. There is nothing in her recent findings to indicate that perturbations to the nervous system are primary drivers of IS. So from that stand point, the disc (mis)shape and Wise's work are not really at odds (yet).
Anyone who wants to suggest the nervous system as the primary point of malfunction triggering IS has a lot of explaining (away) to do about the coincidence of curvature with puberty in girls. That puts it squarely with genes controlling hormone production (or cascading to something related). It may be one huge coincidence but that doesn't seem likely. But what do I know?
Sharon, mother of identical twin girls with scoliosis
No island of sanity.
Question: What do you call alternative medicine that works?
"We are all African."