Results 1 to 8 of 8

Thread: Ostinol / Oral BMPs

  1. #1
    Join Date
    Nov 2010
    Location
    Los Angeles
    Posts
    139

    Ostinol / Oral BMPs

    Does anyone know anything about Ostinol? It supposedly contains Bone Morphogenetic Proteins which, if effective, might be the only supplement that not just strengthens bones, but actually stimulates growth. I'm skeptical since it seems to be provided only by naturopaths and is sold combined with a bunch other supplements known to help with any bone or joint conditions -- either calcium and D3, or glucosamine and chondroitin. So maybe they're just adding a tiny bit and calling it something new?

    It seems to me if it is actually effective then it would have benefits for just about everyone on here so I figure its worth asking. Has anyone's doc told them anything about it? Anyone taking it?
    1993, Age 13, 53* Right T Curve w/ Left L compensatory
    2010, Age 30, 63* or 68* (depending on the doc) Right T Curve w/ Left L compensatory

    http://livingtwisted.wordpress.com/

  2. #2
    Join Date
    Nov 2010
    Location
    St. Louis, MO
    Posts
    86
    I have not heard anything about it...sounds like a question for your doctor/surgeon.
    Laurie Anne
    Age 30
    Pre-Op Curves T68, L80, Kyphosis 48 degrees
    Post-Op Curves both around 10 degrees
    Surgery with Dr. Lenke & Dr. Kelly 12/13/10
    Gained 2.5 inches now 5'9
    PRE-OP Photos: http://s1080.photobucket.com/albums/...urieScoliosis/
    5 Mos Post Op: http://s1080.photobucket.com/albums/...s%20Post%20Op/
    1-Year Post Op: http://s1080.photobucket.com/albums/...r%20Post%20Op/

  3. #3
    Join Date
    Jan 2008
    Location
    NC
    Posts
    8,120
    Proteins get denatured (unfolded) during digestion under the acidic conditions in the stomach or decomposed (broken down to the constituent amino acids or further to other compounds) by the bacteria in the gut. That's why there is no effective oral insulin for Type I diabetics. I don't see why the same issue wouldn't result in total destruction of bone morphogenic protein also.

    Did they address this issue at all?
    Sharon, mother of identical twin girls with scoliosis

    No island of sanity.

    Question: What do you call alternative medicine that works?
    Answer: Medicine


    "We are all African."

  4. #4
    Join Date
    Nov 2010
    Location
    Los Angeles
    Posts
    139
    Quote Originally Posted by Pooka1 View Post
    Proteins get denatured (unfolded) during digestion under the acidic conditions in the stomach or decomposed (broken down to the constituent amino acids or further to other compounds) by the bacteria in the gut. That's why there is no effective oral insulin for Type I diabetics. I don't see why the same issue wouldn't result in total destruction of bone morphogenic protein also.

    Did they address this issue at all?
    The closest I can find to an answer on their website (http://www.zycalbio.com/index.htm) is:

    Ostinol is absorbed through special receptors in the gastrointestinal tract, bringing this powerful protein complex directly into the body.
    That sounds pretty vague. And on closer examination all of their data is on the benefits of BMP in general, not necessarily Ostinol which is the oral form. Maybe its too new for them to have their own research? Unless anyone has anything positive to say about it, I'm going to assume it's just a more expensive version of the supplements I'm already taking.
    1993, Age 13, 53* Right T Curve w/ Left L compensatory
    2010, Age 30, 63* or 68* (depending on the doc) Right T Curve w/ Left L compensatory

    http://livingtwisted.wordpress.com/

  5. #5
    Join Date
    Nov 2010
    Location
    Los Angeles
    Posts
    139

    Response from ZyCal

    FYI, I emailed them the question through their website last night and got this response this morning:

    While you are correct that most proteins breakdown into amino acids in the gut, BMPs are known to resist acid and enzymatic degradation, thus making them suitable for oral use.
    1993, Age 13, 53* Right T Curve w/ Left L compensatory
    2010, Age 30, 63* or 68* (depending on the doc) Right T Curve w/ Left L compensatory

    http://livingtwisted.wordpress.com/

  6. #6
    Join Date
    Jan 2008
    Location
    NC
    Posts
    8,120
    Quote Originally Posted by mehera View Post
    FYI, I emailed them the question through their website last night and got this response this morning:
    Wow good work getting a response on that!

    I'd like to see the stability data before accepting that response at face value. I am not clear why those proteins would be more stable at (extremely) low pH and exactly how they are protected from extracellular (or intracellular for that matter) proteases.

    I'll try to chase this down.
    Sharon, mother of identical twin girls with scoliosis

    No island of sanity.

    Question: What do you call alternative medicine that works?
    Answer: Medicine


    "We are all African."

  7. #7
    Join Date
    Jan 2008
    Location
    NC
    Posts
    8,120
    Okay I searched a bit adn found BMP-2 in a table of proteins that needed to be packaged such that they can be delivered orally.

    http://www.touchbriefings.com/pdf/17...7_whitaker.pdf

    This document is from 2002 and says BMP-2 was in a Phase III trial.

    This is outside my field but I take it from this that at least BMP-2 requires chemical modification in order to deliver it orally.

    So the response you received would seem to refer to another BMP (which doesn't make sense as it would have a similar problem it seems).

    Alternately, they are using a stabilized form in which case, why didn't the response mention that?

    If it is BMP-2 and not stabilized then the oral delivery route seems questionable.

    Just my opinion.
    Sharon, mother of identical twin girls with scoliosis

    No island of sanity.

    Question: What do you call alternative medicine that works?
    Answer: Medicine


    "We are all African."

  8. #8
    Join Date
    Nov 2010
    Location
    Los Angeles
    Posts
    139
    I'm in way over my head at this point. Thanks for your input.
    1993, Age 13, 53* Right T Curve w/ Left L compensatory
    2010, Age 30, 63* or 68* (depending on the doc) Right T Curve w/ Left L compensatory

    http://livingtwisted.wordpress.com/

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •