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Numerous Studies Find Relationship Between Low Vitamin D & Scoliosis

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  • Numerous Studies Find Relationship Between Low Vitamin D & Scoliosis

    Here is a document dump for anyone interested. Feel free to start a lunch room food-fight below but I'm just posting the data. I'll stop back if anything interesting pops up in the world of Scoliosis.

    2016, April 15
    Vitamin-D measurement in patients with adolescent idiopathic scoliosis.
    Our retrospective study compared vitamin-D levels in 229 patients with adolescent idiopathic scoliosis (AIS) and 389 age-matched controls, and evaluated the correlation between vitamin-D levels and sex, Cobb's angle, and serum levels of calcium (Ca), phosphorus, and alkaline phosphatase in the AIS group. Vitamin-D levels were lower in the AIS group, with no sex-specific effects, indicative of a possible vitamin-D resistance in AIS. Vitamin-D levels correlated positively with Ca levels and negatively with Cobb's angle, indicative of a possible role of vitamin D in the etiopathogenesis of AIS. Patients with AIS should be monitored for vitamin-D deficiency/insufficiency.
    2016, April
    Association of Calcium and Phosphate Balance, Vitamin D, PTH, and Calcitonin in Patients With Adolescent Idiopathic Scoliosis.
    RESULTS: Reduction in the serum levels of 25-OH-D3 and calcitonin in girls with AIS compared with healthy girls was demonstrated.

    CONCLUSION: The phosphate-calcium balance and PTH level seem to be normal in patients with AIS. The calcitonin level in girls with AIS is 2-fold lower than in healthy subjects. It is possible that the deficiency of vitamin D can be involved in AIS.
    2014, April 4
    VITAMIN D DEFICIENCY IN PATIENTS WITH ADOLESCENT IDIOPATHIC SCOLIOSIS (AIS): A CAUSE FOR CONCERN?
    Discussion: Vitamin D insufficiency is associated with worse pre-operative outcome scores in the AIS population. We are currently recruiting more patients into our study and also plan to look at the post-operative outcome scores to see if this difference is maintained.
    2014, Dec 4
    Association between vitamin D serum levels and adolescent idiopathic scoliosis
    Results
    The majority of the patients in both groups are non-black females. On group 1 (controls), 63,3% showed abnormal vitamin D levels, while 91% of AIS patients presented low vitamin D level. The mean BMI were 19,6 kg/m2 for controls and 20,3 kg/m2 on group 2. Statistical analysis through unpaired t tests found relevant difference (p<0.0001) between vitamin D levels. The mean and bottom levels of vitamin D were respectively 27 and 13,6 ng/ml for group 1 and 18,8 and 3,13 ng/ml for AIS.

    Conclusions
    There are many factors interacting with vitamin D levels and based on our findings an association of serum 25-OHVitD and AIS could be demonstrated.
    2008, July 15
    The role of initial bone mineral status in predicting the early outcome of brace treatment in girls with adolescent idiopathic scoliosis
    CONCLUSIONS: Osteopenia might be an independent risk factor in the curve progression during brace treatment. The analysis of initial BMD status before bracing may help to predict the outcome of brace treatment.
    2005, Dec
    Osteopenia: a new prognostic factor of curve progression in adolescent idiopathic scoliosis.
    RESULTS: The overall prevalence of curve progression was 50%. The prevalence of osteopenia at the spine and hips was 27.5% and 23.1%, respectively. A larger initial Cobb angle (odds ratio = 4.6), a lower Risser grade (odds ratio = 4.7), premenarchal status (odds ratio = 2.5), osteopenia in the femoral neck of the hip on the side of the concavity (odds ratio = 2.3), and a younger age at the time of diagnosis (odds ratio = 2.1) were identified as risk factors in predicting curve progression. A predictive model was established, and the area under the receiver operating characteristic curve of the model was 0.80 (p < 0.01).

    CONCLUSION: Osteopenia may be an important risk factor in curve progression.
    1999, June 15
    Persistent osteopenia in adolescent idiopathic scoliosis. A longitudinal follow up study.
    CONCLUSIONS: Patients with adolescent idiopathic scoliosis are at increased risk of osteoporosis than are healthy adolescents. The lower rate of increase of bone mineral density in patients with adolescent idiopathic scoliosis who have low bone mineral density could predict a significantly lower peak bone mass in adulthood, with all the associated problems of osteoporosis. Further investigation is needed to define whether osteopenia-associated scoliosis has the same cause, pathogenetic mechanism, and risk of progression when compared with adolescent scoliosis without osteopenia.
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